Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat.
J Endocrinol Invest
; 29(11): RC31-4, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17259788
ABSTRACT
We studied the effect of the acute central administration of obestatin on food intake and body weight in short-term starved male rats, and those of 28-day continuous intracerebroventricular (icv) infusion of obestatin in free feeding rats. In 16-h starved rats, obestatin induced a trend toward a reduction of food intake that did not reach statistical significance. In fed rats, the icv infusion of obestatin significantly decreased food consumption in the first day of treatment; but the anorexigenic effect of obestatin vanished thereafter. Interestingly, the body weight of rats infused for 28 days with obestatin was superimposable to that of the respective control at all time intervals. In all, our results indicate that the anorexigenic effect of obestatin is of little account and that the peptide does not modify energy metabolism in the long-term administration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peso Corporal
/
Hormônios Peptídicos
/
Ingestão de Alimentos
Limite:
Animals
Idioma:
En
Revista:
J Endocrinol Invest
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Itália