[Changes in the percentage of activated lymphocytes in bronchoalveolar lavage fluid in patients with clinical improvement of sarcoidosis]. / Zmiany w populacji limfocytów w popluczynach oskrzelowo-pecherzykowych u chorych z poprawa kliniczna sarkoidozy.

ABSTRACT

UNLABELLED Sarcoidosis is characterized by an accumulation of the activated lymphocytes in affected organs. The aim of the study was the analysis of lymphocytes activation markers in a bronchoalveolar lavage fluid (BALF) in sarcoidosis and the influence of the disease outcome on the changes of cells subpopulations. MATERIAL AND METHODS: We performed the study on 12 patients with the regression of sarcoidosis after the mean period of the observation 8.1 +/- 3.8 months. RESULTS: We observed a tendency toward a BALF cellularity normalization lowering of the percentage of CD4+ lymphocytes (mean 67.1% vs. 57.8%, p = 0.047), lowering of the CD4+/CD8+ ratio (mean 6.3 +/- 5.4 vs. 3.7 +/- 5.2, p < or = 0.05), lowering of the percentage of HLA-DR+ lymphocytes (mean 65% < or = 16.4 vs. 43.9% +/- 18.0, p = 0.05), lowering of the percentage of CD25+ lymphocytes (mean 5.7% vs. 3.1%, p < or = 0.05) and CD4+CD25+ (mean 4.0% vs. 2.4%, p = 0.011). CONCLUSION: The clinical improvement of sarcoidosis is accompanied by the lowering of the percentage of activated lymphocytes in BALF.