Your browser doesn't support javascript.
loading
Association among C-reactive protein, Fatty liver disease, and cardiovascular risk.
Lizardi-Cervera, Javier; Chavez-Tapia, Norberto C; Pérez-Bautista, Oliver; Ramos, Martha H; Uribe, Misael.
Afiliação
  • Lizardi-Cervera J; Department of Gastroenterology, Medica Sur Clinic & Foundation, Puente de Piedra 150, Col. Toriello Guerra, Mexico City, Mexico. jlizardi@medicasur.org.mx
Dig Dis Sci ; 52(9): 2375-9, 2007 Sep.
Article em En | MEDLINE | ID: mdl-17458697
ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is associated with several metabolic disturbances involving inflammation. Ultrasensitive C-reactive protein (uCRP), a marker of coronary heart disease and other chronic diseases, has not been investigated in NAFLD. We tested the relationship between uCRP and NAFLD in middle-aged asymptomatic subjects, independently of other metabolic disturbances associated with metabolic syndrome and cardiovascular risk. We compared 310 subjects with steatosis visible on ultrasound (cases) with 630 and without (controls). Body mass index (BMI), blood pressure and serum levels of uCRP, glucose, lipids, and lipoproteins were measured in all subjects. Differences between groups and the impact of serum uCRP levels were tested by univariate and multivariate logistic regression analysis. Cases were statistically different from controls in the frequency of metabolic syndrome (66.4% vs. 26.7%; P < 0.001). Cases were significantly older (P < 0.001), and had significantly higher values for BMI, glucose, total cholesterol and triglycerides (P < 0.001), and mean uCRP concentrations (4.5 vs. 2.79 mg/L; P < 0.001). By univariate analysis, variables significantly associated with cases were glucose (OR, 4.09; 95% CI, 2.98-5.61), BMI (OR 5.54; 95% CI, 4.09-7.49), and uCRP (OR 7.06; 95% CI, 4.51-11.02). By multivariate analysis, uCRP levels were associated with hepatic steatosis (OR 5.83; 95% CI, 3.07-11.06). Cardiovascular risk was also higher in subjects with NAFLD (4.7 vs. 2.8). Subjects with hepatic steatosis showed an increased concentration of uCRP independently of other metabolic disturbances; this suggests an increased risk of cardiovascular diseases and could be used as a marker of chronic inflammation.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Doenças Cardiovasculares / Fígado Gorduroso Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Dig Dis Sci Ano de publicação: 2007 Tipo de documento: Article País de afiliação: México
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Doenças Cardiovasculares / Fígado Gorduroso Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Dig Dis Sci Ano de publicação: 2007 Tipo de documento: Article País de afiliação: México