Packing features of the all-AT oligonucleotide d(AAATTT).
J Biomol Struct Dyn
; 24(6): 547-52, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17508776
ABSTRACT
We describe the packing features of the oligonucleotide duplex d(AAATTT)2, as determined by X-ray diffraction. There is little information on sequences that only contain A and T bases. The present structure confirms that these sequences tend to pack as a helical arrangement of stacked oligonucleotides in a B conformation with Watson-Crick hydrogen bonding. Our results demonstrate that the virtual TA base step between stacked duplexes has a negative twist that improves base stacking. This observation is consistent with the low stability of TA base steps in B-form DNA.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligodesoxirribonucleotídeos
Idioma:
En
Revista:
J Biomol Struct Dyn
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Espanha