An update on the amyloid hypothesis.
Neurol Clin
; 25(3): 669-82, vi, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17659184
ABSTRACT
Alzheimer's disease (AD) is a devastating neurodegenerative disease. To rationally develop novel therapeutic and/or preventative agents for AD, an understanding of the etiology and pathogenesis of this complex disease is necessary. This article examines the evidence for the amyloid hypothesis of AD pathogenesis and discusses how it relates to the neurological and neuropathological features of AD, the known genetic risk factors and causative mutations, and the heightened risk associated with advanced age.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos beta-Amiloides
/
Doença de Alzheimer
/
Amiloidose
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Animals
/
Humans
Idioma:
En
Revista:
Neurol Clin
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos