Using unsymmetrical indirect covariance processing to calculate GHSQC-COSY spectra.
J Nat Prod
; 70(9): 1393-6, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17691750
ABSTRACT
GHSQC-TOCSY experiments allow sorting of proton-proton connectivity information as a function of (13)C chemical shift. GHSQC-TOCSY is a relatively insensitive 2D NMR experiment. Given two coherence transfer experiments, A --> B and A --> C, it is possible to indirectly determine B <--> C. Unsymmetrical indirect covariance processing of a (1)H- (13)C GHSQC and a GCOSY spectrum afforded a GHSQC-COSY spectrum, with an information content analogous to a GHSQC-TOCSY experiment. However, GHSQC-TOCSY is of significantly lower sensitivity and the data require considerably more time to acquire than either of the component experiments. Investigators needing access to GHSQC-TOCSY type data can, in principle, access it from more readily acquired 2D NMR data. Strychnine ( 1) was used as a model compound to illustrate this capability.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estricnina
/
Espectroscopia de Ressonância Magnética
/
Modelos Químicos
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos