AZF microdeletions and partial deletions of AZFc region on the Y chromosome in Moroccan men.
Asian J Androl
; 9(5): 674-8, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17712485
ABSTRACT
AIM:
To evaluate for the first time the frequency of Y chromosome microdeletions and the occurrence of the partial deletions of AZFc region in Moroccan men, and to discuss the clinical significance of AZF deletions.METHODS:
We screened Y chromosome microdeletions and partial deletions of the AZFc region of a consecutive group of infertile men (n = 149) and controls (100 fertile men, 76 normospermic men). AZFa, AZFb, AZFc and partial deletions of the AZFc region were analyzed by polymerase chain reaction (PCR) according to established protocols.RESULTS:
Among the 127 infertile men screened for microdeletion, four subjects were found to have microdeletions two AZFc deletions and two AZFb+AZFc deletions. All the deletions were found only in azoospermic subjects (4/48, 8.33%). The overall AZFc deletion frequency was low (4/127, 3.15%). AZF microdeletions were not observed in either oligoasthenoteratozoospermia (OATS) or the control. Partial deletions of AZFc (gr/gr) were observed in a total of 7 of the 149 infertile men (4.70%) and 7 partial AZFc deletions (gr/gr) were found in the control group (7/176, 3.98%). In addition, two b2/b3 deletions were identified in two azoospermic subjects (2/149, 1.34%) but not in the control group.CONCLUSION:
Our results suggest that the frequency of Y chromosome AZF microdeletions is elevated in individuals with severe spermatogenic failure and that gr/gr deletions are not associated with spermatogenic failure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Plasma Seminal
/
Cromossomos Humanos Y
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Asian J Androl
Assunto da revista:
MEDICINA REPRODUTIVA
/
UROLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Marrocos