[Apoptosis-related gene expression of human villous trophoblasts exposed to 50 Hz magnetic field].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 25(10): 581-5, 2007 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-18070494
ABSTRACT
OBJECTIVE:
To study apoptosis-related gene expression of human villous trophoblasts exposed to 50 Hz magnetic field and to investigate the possible mechanism of human reproductive health effects caused by 50 Hz magnetic field.METHODS:
Cultured human villous trophoblasts were exposed to 50 Hz magnetic field at 0.4 mT for 6, 48, 72 hours. Gene expressions of Bcl-2, Bax, Caspase-3, p53 and Fas were analyzed using real-time reverse transcription polymerase chain reaction (RT-PCR) assay.RESULTS:
Within 72 hours, the average fold change for each gene was near 1.00, and there was no significant difference on expression pattern in each gene between exposure and control groups (P > 0.05).CONCLUSION:
0.4 mT 50 Hz magnetic field does not affect the apoptosis-related gene expression of human villous trophoblasts in vitro.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trofoblastos
/
Campos Magnéticos
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
Zh
Revista:
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
Assunto da revista:
MEDICINA OCUPACIONAL
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
China