Paramphistomicidal efficacy of an experimental compound in sheep.
Parasitol Res
; 102(4): 705-8, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18185943
ABSTRACT
The aim of the present study was to determine the paramphistomicidal efficacy of methyl [5-chloro-6-(1-naphthyloxy)-1H-benzimidazol-2-yl]carbamate (alpha-carbamate) in experimentally infected sheep. Sixteen crossbred rams were infected each with 600 metacercariae of Calicophoron calicophorum. Forty five days after infection, they were divided into four groups of four animals each. Groups 1 to 3 received compound alpha-carbamate at a dose of 12, 18, and 24 mg/kg b/w, respectively; group 4 serving as the nontreated control. Ten days after treatment, all animals were killed to obtain the rumen and collect, measure, and quantify the trematodes present. Efficacy was assessed as the percentage of trematode reduction of the treated groups relative to the nontreated control. The obtained efficacy indicated a percentage reduction of 86.7%, 97.5%, and 100% for groups 1, 2, and 3, respectively. This experimental compound showed high efficacy against 45-day-old C. calicophorum in experimentally infected sheep.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Ovinos
/
Trematódeos
/
Infecções por Trematódeos
/
Benzimidazóis
/
Anti-Helmínticos
/
Naftalenos
Limite:
Animals
Idioma:
En
Revista:
Parasitol Res
Assunto da revista:
PARASITOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article