Maternal reports of family history from the National Birth Defects Prevention Study, 1997-2001.
Genet Med
; 10(1): 37-45, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-18197055
ABSTRACT
PURPOSE:
To assess usefulness of family history information obtained in pediatric practice, we evaluated maternally reported family history data.METHODS:
We analyzed family history responses from the National Birth Defects Prevention Study using interview data from mothers of children with birth defects (n = 9,331) and of unaffected liveborn children (n = 3,390) with 1997-2001 estimated delivery dates. We examined the effects of demographic factors, case-control status, and type of defect on birth defect family history reports. Interview information was compared with occurrence of prenatal testing.RESULTS:
Among case mothers, 1,577 (17%) reported a first- or second-degree relative with a birth defect, compared with 327 (10%) control mothers (odds ratio = 1.91, 95% confidence interval = 1.68-2.16). Reports of affected relatives were also more frequent among mothers who were non-Hispanic white, were 25 years or older, had more than 12 years of education, had an annual household income greater than $20,000, were born in the United States, and completed an English-language interview.CONCLUSION:
Reporting a family history of birth defects might be influenced by maternal demographic factors, which should be considered in developing pediatric family history tools.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anormalidades Congênitas
/
Anamnese
/
Mães
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Infant
/
Pregnancy
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Genet Med
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos