SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levels.
BMC Genomics
; 9: 41, 2008 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-18221515
ABSTRACT
BACKGROUND:
Accurate analyses of comprehensive genome-wide SNP genotyping and gene expression data sets is challenging for many researchers. In fact, obtaining an integrated view of both large scale SNP genotyping and gene expression is currently complicated since only a limited number of appropriate software tools are available.RESULTS:
We present SNPExpress, a software tool to accurately analyze Affymetrix and Illumina SNP genotype calls, copy numbers, polymorphic copy number variations (CNVs) and Affymetrix gene expression in a combinatorial and efficient way. In addition, SNPExpress allows concurrent interpretation of these items with Hidden-Markov Model (HMM) inferred Loss-of-Heterozygosity (LOH)- and copy number regions.CONCLUSION:
The combined analyses with the easily accessible software tool SNPExpress will not only facilitate the recognition of recurrent genetic lesions, but also the identification of critical pathogenic genes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 7
/
Software
/
Genoma Humano
/
Dosagem de Genes
/
Perfilação da Expressão Gênica
/
Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Health_economic_evaluation
Limite:
Humans
Idioma:
En
Revista:
BMC Genomics
Assunto da revista:
GENETICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Holanda