NPC1L1 and SR-BI are involved in intestinal cholesterol absorption from small-size lipid donors.
Lipids
; 43(5): 401-8, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18373109
ABSTRACT
In the human intestinal content after a meal, cholesterol is dispersed in a complex mixture of emulsified droplets, vesicles, mixed micelles and precipitated material. The aim of this study was to determine the contribution of the main intestinal cholesterol transporters (NPC1L1, SR-BI) to the absorption processes, using different cholesterol-solubilizing donors. Cholesterol donors prepared with different taurocholate concentrations were added to an apical medium of differentiated TC7/Caco-2 cells. As the taurocholate concentrations increased, cholesterol donor size decreased (from 712 to 7 nm in diameter), which enhanced cholesterol absorption in a dose-dependent manner (38-fold). Two transport processes were observed (1) absorption from large donors exhibited low-capacity transport with no noticeable transporter contribution; (2) efficient cholesterol absorption occurs from small lipid donors (
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colesterol na Dieta
/
Receptores Depuradores Classe B
/
Absorção Intestinal
/
Proteínas de Membrana
Limite:
Humans
Idioma:
En
Revista:
Lipids
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França