A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult.
Brain Tumor Pathol
; 25(1): 45-9, 2008.
Article
em En
| MEDLINE
| ID: mdl-18415666
ABSTRACT
Central nervous system (CNS) neuroblastoma/ganglioneuroblastoma is one of the embryonal tumors with neuronal differentiation found in young adults, but it is most common in children, especially in those below the age of 5 years, whereas extraventricular neurocytoma, a rare neuroepithelial tumor with neuronal differentiation, mostly affects young adults. Here we present a rare case of cerebral ganglioneuronal tumor that occurred in a 32-year-old woman. The patient suffered from tonic convulsion, and computed tomography demonstrated a well-demarcated, round tumor 3.3 cm in size with marked calcification in the right parietal lobe. Histological analysis revealed diffuse infiltration of small, round cells with scattered large ganglion-like cells. Immunohistochemically, the tumor cells did not react with any neuronal molecules, except for chromogranin A in ganglion-like large tumor cells, but electron microscopy demonstrated the presence of synapse-like nerve terminal structures without mature postsynaptic density, suggesting the presence of neoplastic tumor components with neuronal differentiation; thus, this tumor was diagnosed as CNS ganglioneuroblastoma with possible low-grade malignancy because the Mib-1 labeling index was less than 3%-4%. Here we discuss the histological entity of cerebral ganglioneuronal tumors, including extraventricular neurocytoma.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lobo Parietal
/
Neoplasias Encefálicas
/
Ganglioneuroblastoma
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Brain Tumor Pathol
Assunto da revista:
CEREBRO
/
NEOPLASIAS
/
PATOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Japão