Topical and oral ketorolac administration increases the intraocular pressure-lowering effect of latanoprost.
Curr Eye Res
; 33(5): 477-82, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18568885
ABSTRACT
PURPOSE:
To verify the influence of a non-steroidal anti-inflammatory drug (NSAID), ketorolac (topical and oral) on the intraocular pressure reduction induced by 0.005% latanoprost topical administration, both in patients affected by primary open-angle glaucoma and in healthy controls.METHODS:
Two groups of subjects were enrolled for this randomized, prospective, masked clinical study 16 glaucomatous patients well controlled with 0.005% latanoprost eyedrops (group I) and 16 healthy adult volunteers (group II). Group I subjects were treated at one-week intervals with 10 mg of oral ketorolac, oral placebo, topical ketorolac, and topical placebo, respectively; for each administration modality, the switch between drug and placebo was performed in a randomized, crossover, double-blind fashion. Group II subjects followed the same protocol, with the topical once-daily 0.005% latanoprost treatment starting three days prior to the ketorolac/placebo administration. Intraocular pressure (IOP) was investigated in both groups on the day of oral/topical administration of ketorolac or placebo at baseline (800 AM) and at the following intervals 1, 2, 4, 8, 12, and 24 hours.RESULTS:
No significant IOP changes after oral and topical placebo administration were observed in either group. In contrast, when the subjects received ketorolac (either oral or topical), a marked decrease in IOP was recorded, with a noticeable fall at the first hour after the NSAID administration (p = 0.01), which remained still significant 8 hours later (p < 0.05).CONCLUSION:
Topical and oral ketorolac strengthens the latanoprost-induced IOP-lowering effect both in glaucomatous patients and in healthy subjects.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prostaglandinas F Sintéticas
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Anti-Inflamatórios não Esteroides
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Glaucoma de Ângulo Aberto
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Cetorolaco
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Pressão Intraocular
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Anti-Hipertensivos
Tipo de estudo:
Clinical_trials
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Guideline
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Observational_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Curr Eye Res
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Itália