Commitment in apoptosis: slightly dead but mostly alive.
Trends Cell Biol
; 18(8): 353-7, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18603426
ABSTRACT
Although the molecular players are well known, the signaling thresholds that shape the decision of a cell to undergo apoptosis remain poorly understood. Using quantitative single-cell analysis approaches, a recent study has generated new insight into the molecular events that influence individual cell-death decisions. Surprisingly, this study demonstrates that cells partly committed to apoptosis can recover and also indicates, although this is as yet unproven, that such cells might harbor DNA damage that could act as a driver of oncogenesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Apoptose
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Irlanda