Association of glucose transporter 1 polymorphisms with type 2 diabetes in the Tunisian population.
Diabetes Metab Res Rev
; 24(7): 544-8, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18613291
ABSTRACT
BACKGROUND:
T2DM is a complex metabolic disease. Genetic studies on T2DM have been of little help so far because several genetic association studies have shown conflicting results. In this study, we report the findings of a case-control study on three SNPs in the GLUT1 gene. For this, we investigated the association of GLUT1 genotypes and haplotypes with T2DM. RESEARCH DESIGN ANDMETHODS:
All 273 T2DM subjects (cases) and 343 healthy subjects (controls) were genotyped using the polymerase chain reaction restriction fragment length polymorphism.RESULTS:
Results showed that the GT genotype of XbaI SNP could increase the risk of susceptibility to T2DM to 2.4 and that TAT is a 'risk haplotype' conferring a risk of 3.4 to T2DM.CONCLUSION:
The TAT haplotype of the GLUT1 gene confers susceptibility to T2DM in the Tunisian population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Nucleotídeo Único
/
Diabetes Mellitus Tipo 2
/
Transportador de Glucose Tipo 1
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Africa
Idioma:
En
Revista:
Diabetes Metab Res Rev
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Tunísia