Familial Mediterranean fever gene as a possible modifier of Sweet syndrome with chronic myelogenous leukemia.
Acta Haematol
; 120(1): 57-62, 2008.
Article
em En
| MEDLINE
| ID: mdl-18824843
ABSTRACT
Sweet syndrome is a multisystem inflammatory disorder characterized by acute fever, as well as painful erythematous plaques infiltrated with mature neutrophils in the absence of vasculitis. The pathogenesis of the disease has not yet been clarified, although several proinflammatory cytokines have been reported to be involved in the disease process. We describe here a patient clinically diagnosed with Sweet syndrome with chronic myelogenous leukemia. The mutational analysis of the patient revealed a compound heterozygous E148Q/R202Q mutation in exon 2 of MEFV gene, which is a causative gene for familial Mediterranean fever. This is the first report to describe MEFV gene mutations in Sweet syndrome. Our results suggest that Sweet syndrome may be mediated though similar inflammatory mechanisms to those of familial Mediterranean fever.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Febre Familiar do Mediterrâneo
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
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Síndrome de Sweet
/
Proteínas do Citoesqueleto
Limite:
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Acta Haematol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Japão