Fullerene water suspension (nC60) exerts antibacterial effects via ROS-independent protein oxidation.
Environ Sci Technol
; 42(21): 8127-32, 2008 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-19031913
ABSTRACT
Buckminsterfullerene (C60) can form water suspensions (nC60) that exert toxic effects. While reactive oxygen species (ROS) generation has been implicated as the mechanism for mammalian cytotoxicity, we propose that nC60 exerts ROS-independent oxidative stress in bacteria, with evidence of protein oxidation, changes in cell membrane potential, and interruption of cellular respiration. This mechanism requires direct contact between the nanoparticle and the bacterial cell and differs from previously reported nanomaterial antibacterial mechanisms that involve ROS generation (metal oxides) or leaching of toxic elements (nanosilver).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Água
/
Espécies Reativas de Oxigênio
/
Fulerenos
/
Antibacterianos
Idioma:
En
Revista:
Environ Sci Technol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos