When should we perform prophylactic antibiotics in elective cesarean cases?
Arch Gynecol Obstet
; 280(1): 13-8, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19034470
ABSTRACT
OBJECTIVE:
The aim of this study was to determine whether the timing of prophylactic antibiotics at cesarean delivery influences maternal and neonatal infectious morbidity. STUDYDESIGN:
This was a prospective, randomized trial. Four hundred patients that underwent elective cesarean section between June and December 2007 formed the study population. Eleven patients were excluded from the study because they needed transfusion during the cesarean section. The population was divided into two groups Group A, antibiotic prophylaxis was applied to 194 women before skin incision and Group B, antibiotic prophylaxis was applied to 195 women after umbilical cord clamping. The occurrence of endomyometritis/endometritis, wound infection, febrile morbidity, total infectious morbidity, and neonatal complications were compared.RESULTS:
There were 389 patients enrolled. No demographic differences were observed between groups. No significant difference was found between the groups for total infectious morbidity [relative risk (RR) 1.39, 95% confidence interval (CI) 0.71-2.69] and endometritis (RR 1.40, 95% CI 0.43-4.51). There was no increase in neonatal sepsis (RR 1.47, 95% CI 0.61-3.53), sepsis workup (RR 1.35, 95% CI 0.75-2.42), need for neonatal intensive care (RR 1.77, 95% CI 0.51-6.16), and intensive care stay period (P = 0.16).CONCLUSIONS:
Time of antibiotic prophylaxis application does not change maternal infectious morbidity in cesarean section deliveries. Preoperative prophylaxis application does not affect neonate morbidity rates as stated in literature.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Complicações Infecciosas na Gravidez
/
Infecções Bacterianas
/
Cesárea
/
Antibioticoprofilaxia
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Arch Gynecol Obstet
Assunto da revista:
GINECOLOGIA
/
OBSTETRICIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Turquia