[The role of inflammatory factors in pathogenesis of ischemic heart disease].

ABSTRACT

PURPOSE: To study mechanisms of immune derangements in coronary heart disease (CHD). MATERIAL AND METHODS: We measured basic markers of immune activation in 43 patients with CHD and NYHA I-IV class heart failure (HF). There were 41 men and 2 women aged 33 - 64 years (mean 48 +/- 8 years). Concentrations of hsCRP, IgA, IgM, IgG were measured using commercially available kits. IL-8, sIL-2R, IL-6, IL-18, IL-10, IFN-gamma endothelin levels were measured using enzyme-linked immunosorbent assay method. RESULTS: We found evidence of participation of proinflammatory factors in pathogenesis of HF and established associations of mediators of inflammation (CRP, IL-8) with severity of HF, endothelial dysfunction, and impairment of cardiac function.