Activation of the granulocyte-monocyte colony stimulating factor gene in acute myeloid leukaemia cells is not related to gene rearrangement.
Leuk Res
; 15(10): 957-61, 1991.
Article
em En
| MEDLINE
| ID: mdl-1921455
ABSTRACT
Several reports have documented that leukaemic blasts produce a number of cytokines among them the granulocyte-monocyte colony stimulating factor (GM-CSF). We analysed the structure of the gene that codes for GM-CSF in 44 acute myeloid leukaemia (AML) cases in an attempt to establish whether the autocrine production of GM-CSF was due to a structural gene alteration. No structural alteration was detected in the GM-CSF gene in any of the 44 cases studied. We, therefore, conclude that the autocrine production of GM-CSF by leukaemia blasts is not dependent on gene rearrangement.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rearranjo Gênico
/
Leucemia Mieloide Aguda
/
Regulação Neoplásica da Expressão Gênica
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Genes
Limite:
Humans
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Itália