Endothelial cells form a phalanx to block tumor metastasis.
Cell
; 136(5): 810-2, 2009 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-19269358
ABSTRACT
Tumor blood vessels deliver oxygen poorly, thereby contributing to tumor hypoxia and upregulation of proangiogenic cytokines in an escalating feedback loop. Mazzone et al. (2009) now show that reducing the amount of a protein involved in endothelial oxygen sensing leads to changes in endothelial cell shape that interrupt this feedback loop and reduce tumor metastasis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasos Sanguíneos
/
Células Endoteliais
/
Hipóxia
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2009
Tipo de documento:
Article