Absolute quantification of human uridine-diphosphate glucuronosyl transferase (UGT) enzyme isoforms 1A1 and 1A6 by tandem LC-MS.
Drug Metab Lett
; 2(3): 210-22, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-19356096
ABSTRACT
UGT enzymes catalyze the formation of glucuronic acid conjugates. Specifically selected representative stable isotope (C(13), N(15)) labeled peptide internal standards of each enzyme were employed to quantify UGTs 1A1 and 1A6 by LC-MS/MS using isotope dilution techniques. Inter day variability (n=5) for human liver microsomes was
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatografia Líquida
/
Glucuronosiltransferase
/
Espectrometria de Massas em Tandem
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Drug Metab Lett
Assunto da revista:
FARMACOLOGIA
/
METABOLISMO
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos