Developmental profiles of lipogenic enzymes and their regulators in the neonatal mouse brain.
Neurochem Res
; 34(11): 1945-54, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19418221
ABSTRACT
It has been shown that lipogenic enzymes, such as fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), are highly expressed in the rodent brain during the early neonatal period and decline thereafter. However, cellular localization of these enzymes is unknown. Presently, we examined developmental changes in the levels and cellular localization of FAS and ACC, and their putative regulators, sterol-regulatory element-binding protein (SREBP)-1 and AMP-activated protein kinase (AMPK) in the mouse brain. Levels of these proteins including phosphorylated forms of ACC and AMPK decreased between postnatal day 4 (P4) and P19. Immunohistochemical studies indicated that FAS, ACC, AMPK, and SREBP-1 were expressed in neurons at P7, while FAS was found mostly in cells of oligodendrocyte lineage at P19. These studies suggest that neurons in the early neonatal brain are involved in do novo fatty acid synthesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetil-CoA Carboxilase
/
Encéfalo
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Proteína de Ligação a Elemento Regulador de Esterol 1
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Proteínas Quinases Ativadas por AMP
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Ácido Graxo Sintases
Limite:
Animals
Idioma:
En
Revista:
Neurochem Res
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos