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Toll-like receptor 2 gene polymorphism and its relationship with SCS in dairy cattle.
Zhang, L P; Gan, Q F; Ma, T H; Li, H D; Wang, X P; Li, J Y; Gao, X; Chen, J B; Ren, H Y; Xu, S Z.
Afiliação
  • Zhang LP; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, P.R. China.
Anim Biotechnol ; 20(3): 87-95, 2009.
Article em En | MEDLINE | ID: mdl-19544205
ABSTRACT
Toll-like receptor 2 (TLR2) plays an important role in the innate immune response to a variety of pathogens. In this study, bovine TLR2 gene was taken as a candidate gene for mastitis resistance. Through PCR-SSCP analysis and sequencing, three missense mutations at T385 G, G398A, and G1884A were detected in the coding region that encoded extracellular domain. Altogether 240 dairy cattle of three breeds (Holstein, Simmental, and Sanhe cattle) were genotyped and allele frequencies were determined. The effects of TLR2 polymorphisms on somatic cell score (SCS) were analyzed and significant association was found between T385 G and SCS. The mean of genotype GG was significantly lower than those of genotype TT and TG. No significant associations were found with SCS for G398A and G1884A. Information provided in this research will be useful in further studies to determine the role of TLR2 gene in the mastitis resistance.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bovinos / Polimorfismo de Nucleotídeo Único / Receptor 2 Toll-Like Limite: Animals Idioma: En Revista: Anim Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bovinos / Polimorfismo de Nucleotídeo Único / Receptor 2 Toll-Like Limite: Animals Idioma: En Revista: Anim Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2009 Tipo de documento: Article