Inhibitory effect of a new antibiotic, guanine 7-N-oxide, on the replication of several RNA viruses.
Antiviral Res
; 14(3): 173-8, 1990 Sep.
Article
em En
| MEDLINE
| ID: mdl-1964374
ABSTRACT
Guanine 7-N-oxide (G-7-Ox) was examined for its antiviral activity against 9 viruses based on plaque reduction, neuraminidase activity reduction, a fluorescent antibody technique or ELISA. The following viruses were included in the tests influenza, Sendai, simian virus 5 (SV5), respiratory syncytial, western equine encephalitis, Japanese encephalitis, vesicular stomatitis, rabies and polio. G-7-Ox showed broad anti-RNA viral activity against all viruses tested, except for poliovirus. Inhibition of persistent SV5 infection by G-7-Ox indicates that its antiviral activity is independent of cytotoxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus de RNA
/
Guanina
Limite:
Animals
Idioma:
En
Revista:
Antiviral Res
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão