A single nucleotide polymorphism in the porcine cathepsin K (CTSK) gene is associated with back fat thickness and production traits in Italian Duroc pigs.
Mol Biol Rep
; 37(1): 491-5, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19662513
ABSTRACT
Cathepsin K (CTSK) was selected as a candidate gene for fat deposition in pigs because recently, in human and mouse, it was shown that this lysosomal proteinase is an obesity marker. A single nucleotide polymorphism (SNP) was identified in intron 4 of the porcine CTSK gene (g.15G>A; FM209043). Allele frequencies of this polymorphism were analysed in seven pig breeds. Radiation hybrid mapping confirmed the localization of CTSK to porcine chromosome 4, close to the FAT1 QTL region. Three populations of pigs (one Italian Large White and two Italian Duroc groups of pigs) were selected for association analysis. In the Italian Large White breed the g.15G>A SNP was not informative. Association analysis including all Italian Duroc pigs showed that the CTSK marker was associated with back fat thickness and lean cuts (P < 0.01), and average daily gain and feedgain ratio (P < 0.05) estimated breeding values.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Característica Quantitativa Herdável
/
Polimorfismo de Nucleotídeo Único
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Sus scrofa
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Adiposidade
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Catepsina K
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Animals
País/Região como assunto:
Europa
Idioma:
En
Revista:
Mol Biol Rep
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Itália