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Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer.
Pereira, Deidre B; Sannes, Timothy; Dodd, Stacy M; Jensen, Sally E; Morgan, Linda S; Chan, Edward K L.
Afiliação
  • Pereira DB; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610-0165, United States. dpereira@phhp.ufl.edu
Brain Behav Immun ; 24(2): 210-4, 2010 Feb.
Article em En | MEDLINE | ID: mdl-19716411
ABSTRACT
Heat shock protein 70 (HSP70), an intracellular chaperone "stress protein," has been identified in the extracellular milieu, where it may exert regulatory effects upon monocytes. HSPs are overexpressed in many cancers and implicated in tumorigenesis. Few studies have examined the relationship between psychosocial factors and HSP levels, particularly in cancer. The purpose of the present study was to examine the relationship between negative psychosocial states (life events stress and negative mood states) and serum concentration of HSP70 antibodies among women with endometrial cancer, the fourth most common cancer among women in the United States. Thirty-six women scheduled to undergo surgery for suspected endometrial adenocarcinoma underwent a psychosocial assessment and peripheral venous blood draw. Life events stress was assessed using an abbreviated version of the Life Experiences Survey; negative mood states were assessed using abbreviated versions of the Structured Interview Guide for the Hamilton Anxiety and Depression Scales and the Profile of Mood States. HSP70 antibody levels were regressed sequentially on life events stress and negative mood variables while controlling for body mass index (BMI) and cancer stage. Results revealed that greater HSP70 antibody concentrations were associated with greater impact of recent negative life events (p=.04), anxious symptomatology (p=.007), depressive symptomatology (p=.03), and total mood disturbance (p=.001) after controlling for BMI and cancer stage. While based on a modest sample size, these preliminary results suggest that larger-scale research exploring the relationships among psychosocial factors and HSP70 in cancer patients may be warranted.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Psicológico / Adenocarcinoma / Neoplasias do Endométrio / Proteínas de Choque Térmico HSP70 / Afeto Tipo de estudo: Prognostic_studies / Qualitative_research Limite: Female / Humans Idioma: En Revista: Brain Behav Immun Assunto da revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Psicológico / Adenocarcinoma / Neoplasias do Endométrio / Proteínas de Choque Térmico HSP70 / Afeto Tipo de estudo: Prognostic_studies / Qualitative_research Limite: Female / Humans Idioma: En Revista: Brain Behav Immun Assunto da revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos