Design and synthesis of novel pinacolylboronate containing combretastatin 'antimitotic agent' analogues.
Tetrahedron Lett
; 50(25): 3031-3034, 2009 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-20037629
ABSTRACT
We developed a procedure to synthesize pinacolyl boronate containing stilbene derivatives and used this procedure to synthesize boron-containing combretastatin analogues. The key step involves the Wittig reaction of the ylide 4-(4,4,5,5-tetramethyl-1,3,2-dioxaboratophenyl)-methyl triphenylphosphonium bromide 11 with 3,4,5-trimethoxy benzaldehyde in the presence of (t)BuONa in DMF, providing 88% yield. We are now in a position to evaluate the biological activity of these derivatives as modulators of TGF-beta signaling pathways.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Tetrahedron Lett
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos