Blood transfusions increase cerebral, splanchnic, and renal oxygenation in anemic preterm infants.
Transfusion
; 50(6): 1220-6, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20113454
ABSTRACT
BACKGROUND:
Multiprobe near infrared spectroscopy (NIRS) has been used to study regional cerebral (rSO(2)C), splanchnic (rSO(2)S), and renal (rSO(2)R) tissue oxygenation in newborns. We used this method to study the effects of red blood cell (RBC) transfusions in anemic preterm infants to assess if thresholds for transfusions were appropriate for recognizing a clinical condition permitting tissue oxygenation improvement. STUDY DESIGN ANDMETHODS:
Multiprobe NIRS (INVOS 5100, Somanetics) was applied during transfusion to 15 preterm infants with symptomatic anemia of prematurity (hematocrit level of <25%). rSO(2)C, rSO(2)S, and rSO(2)R were recorded at selected times, and then fractional oxygen cerebral extraction ratio [FOEC (SaO(2)-rSO(2)C)/SaO(2)], fractional oxygen splanchnic extraction ratio [FOES (SaO(2)-rSO(2)S)/SaO(2)], fractional oxygen renal extraction ratio [FOER (SaO(2)-rSO(2)R)/SaO(2)], cerebrosplanchnic oxygenation ratio [CSOR (rSO(2)S/rSO(2)C)], and cerebrorenal oxygenation ratio [CROR (rSO(2)R/rSO(2)C)] were calculated. In addition, we used Doppler ultrasonography for evaluating cerebral blood flow (CBF), splanchnic blood flow (SBF), and renal blood flow (RBF) velocity.RESULTS:
rSO(2)C, rSO(2)S, and rSO(2)R significantly increased during transfusions, while FOEC, FOES, and FOER decreased. CSOR and CROR increased during transfusions. CBF velocity decreased during the study period, while SBF and RBF velocities did not vary.CONCLUSION:
RBC transfusions performed at used thresholds permitted an increase in cerebral, splanchnic, and renal oxygenation. The associated decreases in oxygen tissue extraction might suggest that transfusions were well timed for preventing tissue hypoxia or too early and theoretically prooxidant. Further studies could help to clarify this issue.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Recém-Nascido Prematuro
/
Cerebelo
/
Transfusão de Eritrócitos
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Anemia Neonatal
/
Rim
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Transfusion
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Itália