Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing.
J Headache Pain
; 11(3): 241-6, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20186560
ABSTRACT
We recruited 49 patients with classical trigeminal neuralgia (TN) according to the latest guidelines of the International Classification of Headache Disorders, and divided them into an acute (=30 days onset; 13 patients) and a chronic (>30 days onset; 36 patients) group. We used blink reflex study and current perception threshold (CPT) testing to evaluate the painful facial areas and contralateral non-painful areas of patients with classical TN. CPT 5 Hz examinations, which correlate with unmyelinated fiber function, showed significantly decreased CPTs in the acute stage (11.62 +/- 6.99 vs. 18.69 +/- 9.66, P = 0.025), but significantly increased CPTs in the chronic stage (26.67 +/- 18.65 vs. 19.69 +/- 13.70, P = 0.010) on the painful side when compared with the contralateral non-painful side. However, CPTs at 250 Hz (Adelta) and 2000 Hz (Abeta) examinations did not show significant differences between the painful and non-painful sides. In contrast, only three (3/49) patients showed an abnormal trigeminal nerve stimulation on the ipsilateral painful side by blink reflex study. The findings suggest that classical TN is not a simple large-myelinated nerve fiber dysfunction but a more complex process with a main dysfunction of unmyelinated nerve fibers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuralgia do Trigêmeo
/
Piscadela
/
Medição da Dor
/
Eletrodiagnóstico
Tipo de estudo:
Diagnostic_studies
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Evaluation_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Headache Pain
Assunto da revista:
MEDICINA INTERNA
/
NEUROLOGIA
/
PSICOFISIOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Taiwan