Diazepam fluorimetric monitoring upon photo-degradation in an automatic miniaturized flow system.
J Fluoresc
; 20(4): 915-22, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20358284
ABSTRACT
The present work describes the fully integration in line of a photo-degradation unit, comprising a low pressure UV lamp, in a Multipumping Flow System (MPFS), for the fluorimetric chemical control of commercially available pharmaceutical formulations containing diazepam. The utilization of an organized micellar medium provided enhanced fluorescence emission. The results allowed to obtain a linear working range for diazepam concentrations of up to 40 mg L(-1) (r = 0.9998) and the detection limit was about 0.97 mg L(-1). The results obtained by the miniaturized and automatic flow system were in agreement with those furnished by the reference procedure, with relative deviations comprised between -2.09% and 2.13%.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diazepam
/
Processos Fotoquímicos
/
Fluorometria
/
Miniaturização
Idioma:
En
Revista:
J Fluoresc
Assunto da revista:
BIOFISICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Portugal