Thermal trap for DNA replication.
Phys Rev Lett
; 104(18): 188102, 2010 May 07.
Article
em En
| MEDLINE
| ID: mdl-20482214
ABSTRACT
The hallmark of living matter is the replication of genetic molecules and their active storage against diffusion. We implement both in the simple nonequilibrium environment of a temperature gradient. Convective flow both drives the DNA replicating polymerase chain reaction while concurrent thermophoresis accumulates the replicated 143 base pair DNA in bulk solution. The time constant for accumulation is 92 s while DNA is doubled every 50 s. The experiments explore conditions in pores of hydrothermal rock which can serve as a model environment for the origin of life.
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Base de dados:
MEDLINE
Assunto principal:
DNA
/
Replicação do DNA
/
Temperatura Alta
/
Modelos Químicos
/
Modelos Genéticos
Idioma:
En
Revista:
Phys Rev Lett
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha