Detection of Plasmodium falciparum-infected red blood cells by optical stretching.
J Biomed Opt
; 15(3): 030517, 2010.
Article
em En
| MEDLINE
| ID: mdl-20615000
ABSTRACT
We present the application of a microfluidic optical cell stretcher to measure the elasticity of malaria-infected red blood cells. The measurements confirm an increase in host cell rigidity during the maturation of the parasite Plasmodium falciparum. The device combines the selectivity and sensitivity of single-cell elasticity measurements with a throughput that is higher than conventional single-cell techniques. The method has potential to detect early stages of infection with excellent sensitivity and high speed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Malária Falciparum
/
Técnicas Analíticas Microfluídicas
/
Eritrócitos
/
Módulo de Elasticidade
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Biomed Opt
Assunto da revista:
ENGENHARIA BIOMEDICA
/
OFTALMOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article