Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists.
Bioorg Med Chem Lett
; 20(15): 4371-5, 2010 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-20615697
ABSTRACT
Hit-to-lead optimization of a HTS hit led to new carbamoyloxime derivatives. After identification of an advanced hit (8d) the CYP enzyme inhibitory activity of this class of compounds was successfully eliminated. Systematic exploration of different parts of the advanced hit led us to some promising lead compounds with mGluR5 affinities comparable to that of MPEP.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Carbamatos
/
Receptores de Glutamato Metabotrópico
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Hungria