Endoglin and CD-34 immunoreactivity in the assessment of microvessel density in normal pituitary and adenoma subtypes.
Neoplasma
; 57(6): 590-3, 2010.
Article
em En
| MEDLINE
| ID: mdl-20845998
ABSTRACT
UNLABELLED Vascularization is a prerequisite of tumor growth, invasion and metastasis. In the present work, microvessel density was assessed by quantitating using two different endothelial cell biomarkers, endoglin (CD-105) and CD-34. Fifty endocrinologically active and 36 clinically nonfunctioning pituitary adenomas, all surgically resected, as well as 10 autopsy-derived normal adenohypophyses were investigated by immunohistochemistry. The results showed that in every pituitary adenoma type endoglin, an assumed biomarker of proliferating endothelial cells, immunostained fewer vessels than CD-34 which revealed immunopositivity in all capillaries. Differences in endoglin versus CD-34 immunoexpression indicate varying degrees of vascularity in pituitary adenoma subtypes. The low levels of endoglin immunoexpression in pituitary tumors exposed to long-acting somatostatin analogs and dopamine agonists are consistent with the view that these agents inhibit angiogenesis. KEYWORDS immunohistochemistry, endoglin, CD34, microvascular density, angiogenesis, pituitary.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipófise
/
Neoplasias Hipofisárias
/
Adenoma
/
Antígenos CD
/
Receptores de Superfície Celular
/
Antígenos CD34
Limite:
Humans
Idioma:
En
Revista:
Neoplasma
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Canadá