Neuropeptides in guinea pig trachea: distribution and evidence for the release of CGRP into tracheal lumen.
Peptides
; 11(6): 1211-6, 1990.
Article
em En
| MEDLINE
| ID: mdl-2087441
ABSTRACT
The airways of the guinea pig are richly innervated by peptide-containing nerve fibers. Among the most abundant neuropeptides are calcitonin gene-related peptide (CGRP) and substance P (SP), which are stored in nerve fibers located predominantly within and beneath the epithelium, and vasoactive intestinal peptide (VIP), which is located in fibers running mainly among smooth muscle bundles and seromucous glands. Sensory denervation (capsaicin treatment) of adult guinea pigs caused an almost total disappearance of CGRP- and SP-containing nerve fibers, while the density of VIP-containing nerve fibers located in smooth muscle seemed to increase. In the isolated trachea, perfused luminally, CGRP was found to appear in the intraluminal fluid after exposure to capsaicin but not after electrical vagal stimulation. CGRP concentrations in the tracheal wall did not change significantly. Luminally applied CGRP did not affect smooth muscle tension, measured as intraluminal volume changes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traqueia
/
Neuropeptídeos
/
Peptídeo Relacionado com Gene de Calcitonina
/
Fibras Nervosas
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Suécia