Terminal differentiation in epithelia: the role of integrins in hensin polymerization.
Annu Rev Physiol
; 73: 401-12, 2011.
Article
em En
| MEDLINE
| ID: mdl-20936943
ABSTRACT
Epithelia, the most abundant cell type, differentiate to protoepithelia from stem cells by developing apical and basolateral membrane domains and form sheets of cells connected by junctions. Following this differentiation step, the cells undergo a second step (terminal differentiation), during which they acquire a mature phenotype, which unlike the protoepithelial one is tissue and organ specific. An extracellular matrix (ECM) protein termed hensin (DMBT1) mediates this differentiation step in the kidney intercalated cells. Although hensin is secreted as a soluble monomer, it requires polymerization and deposition in the ECM to become active. The polymerization step is mediated by the activation of inside-out signaling by integrins and by the secretion of two proteins cypA (a cis-trans prolyl isomerase) and galectin 3.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Integrinas
/
Diferenciação Celular
/
Proteínas da Matriz Extracelular
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Receptores de Superfície Celular
/
Epitélio
/
Receptores Depuradores
/
Polimerização
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Physiol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos