Follicle-stimulating hormone stimulates inhibin in the serum of male monkeys (Macaca mulatta).
Acta Endocrinol (Copenh)
; 122(1): 96-100, 1990 Jan.
Article
em En
| MEDLINE
| ID: mdl-2106192
ABSTRACT
Three adult rhesus monkeys were injected intramuscularly with human FSH at doses of 2, 10 or 25 IU/kg in a cross-over design with 3-week intervals between injections. On each occasion a fourth animal received saline only as control. Serum levels of exogenous FSH were monitored by a fluoroimmunoassay specific for human FSH. Serum inhibin was measured by a heterologous radioimmunoassay. Each FSH injection was followed by a rise in serum inhibin in a dose-dependent manner. The half-life of human FSH in rhesus monkeys ranged from 25.1 to 32.9 h with no significant differences between doses. The rise of inhibin occurred with a lag time of 53.3 to 61.9 h after injection of FSH, independent of the dose administered. These findings support the concept that inhibin secretion in male primates is stimulated by FSH.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Foliculoestimulante
/
Inibinas
Limite:
Animals
Idioma:
En
Revista:
Acta Endocrinol (Copenh)
Ano de publicação:
1990
Tipo de documento:
Article