Inhalation by design: dual pharmacology ß-2 agonists/M3 antagonists for the treatment of COPD.
Bioorg Med Chem Lett
; 21(9): 2759-63, 2011 May 01.
Article
em En
| MEDLINE
| ID: mdl-21075627
ABSTRACT
This paper describes the successful design and development of dual pharmacology ß-2 agonists-M3 antagonists, for the treatment of chronic obstructive pulmonary disorder using the principles of 'inhalation by design'. A key feature of this work is the combination of balanced potency and pharmacodynamic duration with desirable pharmacokinetic and material properties, whilst keeping synthetic complexity to a minimum.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
/
Antagonistas Muscarínicos
/
Doença Pulmonar Obstrutiva Crônica
/
Agonistas de Receptores Adrenérgicos beta 2
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido