Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans.
J Nat Prod
; 74(1): 65-8, 2011 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-21155589
ABSTRACT
A new sesquiterpene benzoxazole, nakijinol B (3), its acetylated derivative, nakijinol B diacetate (6), and two new sesquiterpene quinones, smenospongines B (4) and C (5), were isolated from the methanol extract of the marine sponge Dactylospongia elegans. Also isolated were the known compounds dactyloquinone B and a 11 mixture of ilimaquinone and 5-epi-ilimaquinone. Their structures were determined on the basis of spectroscopic analyses and comparison with literature data. The isolated compounds were assessed for their cytotoxicity against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a normal mammalian cell line (CHO-K1). All compounds were found to have activities in the range 1.8-46 µM and lacked selectivity for tumor versus normal cell lines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Quinonas
/
Sesquiterpenos
/
Benzoxazóis
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Austrália