Detecting structural similarity of ligand interactions in the lipid metabolic system including enzymes, lipid-binding proteins and nuclear receptors.
Protein Eng Des Sel
; 24(4): 397-403, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21216727
ABSTRACT
Nuclear receptors, intracellular lipid-binding proteins and metabolic enzymes are responsible for optimal metabolic homeostasis in higher organisms. Recent studies revealed the specific cooperation/competition among the subfamilies of these proteins. In this study, the nuclear receptor-lipid-binding protein-enzyme system, in which the interactions are mostly mediated by ligand molecules, was examined in terms of their ligand-binding structures to detect the similarity of interactions between functionally related subfamilies. The complex structures were dissected into single amino acid motifs for ligand fragment binding, and the presence and evolutionary origin of the motifs were compared among the protein families. As a result, functionally related nuclear receptor and enzyme pairs were found to share more motifs than expected, in agreement with the fact that the two families compete for the same ligand, and thus our study implies the possible co-evolution of the indirectly interacting protein system.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas de Transporte
/
Receptores Citoplasmáticos e Nucleares
/
Acil-CoA Desidrogenase
/
Proteínas de Ligação a Ácido Graxo
Idioma:
En
Revista:
Protein Eng Des Sel
Assunto da revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão