Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
J Neurosci
; 31(12): 4755-64, 2011 Mar 23.
Article
em En
| MEDLINE
| ID: mdl-21430174
ABSTRACT
L-type calcium channels play only a minor role in basal neurotransmitter release in brain neurons but contribute significantly after induction of plasticity. Very little is known about mechanisms that enable L-type calcium channel participation in neurotransmitter release. Here, using mouse primary cortical neurons, we found that inhibition of Erk1/2 (extracellular signal-regulated kinases 1 and 2) enhanced synaptic vesicle exocytosis by increasing calcium influx through L-type calcium channels. Furthermore, inhibition of Erk1/2 increased the surface fraction of these channels. These findings indicate a novel inhibitory effect of Erk1/2 on synaptic transmission through L-type calcium channels.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vesículas Sinápticas
/
Canais de Cálcio Tipo L
/
MAP Quinases Reguladas por Sinal Extracelular
/
Exocitose
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Neurosci
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos