Reduction in corneal volume with severity of keratoconus.
Curr Eye Res
; 36(6): 522-7, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21501083
ABSTRACT
PURPOSE:
To compare the corneal volume in keratoconic and normal eyes to improve our understanding of the tissue distribution associated with the disease. MATERIALS ANDMETHOD:
The Oculus Pentacam tomographer (Oculus Inc., Wetzlar, Germany) was used to analyze the corneal volume contained within discs with diameters of 3, 5, 7, and 10 mm in 21 patients with keratoconus and 21 matched healthy control subjects.RESULTS:
Corneal volume was significantly decreased in the keratoconus group (keratoconus vs. control group 3.44 ± 0.39 vs. 4.05 ± 0.29 mm(3), 10.34 ± 0.95 vs. 11.79 ± 0.84 mm(3), 22.80 ± 1.73 vs. 25.26 ± 1.74 mm(3), and 57.17 ± 3.94 vs. 61.90 ± 4.12 mm(3) for the 3-, 5-, 7-, and 10-mm diameter discs, respectively; p < 0.001). As the corneal disc diameter analyzed increased, fewer differences were found between the control corneas and keratoconic corneas at different stages of the disease. Within the 3-mm and 5-mm diameter discs, significant differences were detected between the control group, moderate keratoconus, and the severe keratoconus groups (p < 0.05). However, within the 10-mm discs, differences were only detected between the control group and the severe keratoconus group (p = 0.005).CONCLUSIONS:
Corneal volume was significantly decreased in keratoconus, particularly in the central and paracentral area. The decrease in corneal volume in moderate and severe keratoconus as detected by the Pentacam tomographer, may be explained by loss of corneal tissue. In the early stages of the disease, the altered metabolic activity may cause tissue stretching and, as the disease progresses, this stretching is then accompanied by tissue loss.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córnea
/
Imageamento Tridimensional
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Tomografia de Coerência Óptica
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Ceratocone
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Curr Eye Res
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Irlanda