The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer.
Eur J Gynaecol Oncol
; 32(2): 160-3, 2011.
Article
em En
| MEDLINE
| ID: mdl-21614904
ABSTRACT
PURPOSE:
In this study, we compared second-line chemotherapy effects of nodal metastases with other metastases sites.METHODS:
The medical records of 44 women with recurrent ovarian cancer who received second-line chemotherapy were retrospectively reviewed.RESULTS:
Median age at the time of second-line chemotherapy was 55 years (range 31-74). Recurrent sites were as follows 29 patients had a solitary site (abdominal cavity 8; lymph node 3; pelvic cavity 10; liver 4; lung 4) and 15 patients had multiple sites In total, the response rate was 30% (CR 8, PR 5). The response rate in sensitive cases was higher than in refractory/resistant cases (50% vs 5% p = 0.002). However, age, chemotherapy regimen, histologic type and number of diseases were not related with chemotherapy effect. In all diseases, response rate tended to be higher in lymph node disease than in the others (44% vs 27%). In both sensitive and refractory/resistant cases, response rate tended to be higher in lymph node disease.CONCLUSION:
The response rate for lymph node diseases tended to be relatively high. Further study analyzing survival will be required to conclude the chemotherapy effect.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Neoplasias Epiteliais e Glandulares
/
Metástase Linfática
/
Recidiva Local de Neoplasia
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Eur J Gynaecol Oncol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão