Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.
J Nat Prod
; 74(6): 1370-8, 2011 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-21619045
ABSTRACT
Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A-C (1-3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward ß-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC50) 0.68 µM) showed inhibitory activity on ß-glucuronidase enzyme, while 3 (IC50) 7.69 µM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Ficus
/
Enoil-(Proteína de Transporte de Acila) Redutase (NADH)
/
Glucuronidase
/
Isoflavonas
/
Antimaláricos
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Camarões