Backbone and side-chain ¹H, ¹5N, and ¹³C resonance assignments of Norwalk virus protease.
Biomol NMR Assign
; 6(1): 19-21, 2012 Apr.
Article
em En
| MEDLINE
| ID: mdl-21647610
ABSTRACT
Norovirus protease cleaves the virus-encoded polyprotein into six mature nonstructural proteins, presenting itself as an essential enzyme for the viral replication as well as an attractive target for the antiviral drug development. A deeper understanding of the structural mechanism of the protease-substrates/inhibitors interactions by means of solution NMR methods would facilitate a rational design of the virus protease inhibitor. We here report the backbone and side-chain resonance assignment of the protease from Norwalk virus, which is the prototype strain of norovirus. The assignment data has been deposited in the BMRB database under the accession number 17523.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeo Hidrolases
/
Vírus Norwalk
/
Ressonância Magnética Nuclear Biomolecular
Idioma:
En
Revista:
Biomol NMR Assign
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA NUCLEAR
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos