Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells.
Biochem Biophys Res Commun
; 410(2): 328-32, 2011 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-21672521
ABSTRACT
Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2 µM) and/or valproic acid (5 mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lovastatina
/
Protocolos de Quimioterapia Combinada Antineoplásica
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Ácido Valproico
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Tumor Fibroso Solitário Pleural
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Mesotelioma
Limite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão