Fragment A-B of tetanus toxin does not block neuromuscular transmission in the goldfish.
Toxicon
; 28(6): 737-41, 1990.
Article
em En
| MEDLINE
| ID: mdl-2169660
ABSTRACT
While 4 micrograms of Fragment A-B of tetanus toxin (which lacks the binding site for nervous tissue) causes flaccid paralysis and death in mice, 26 micrograms has no toxic effect in goldfish. Antibodies to either A-B or to fragment C (which contains the binding site) block the paralytic effect of whole toxin in goldfish. It is concluded that binding is necessary for the neuromuscular blocking action of the toxin in goldfish.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Toxina Tetânica
/
Transmissão Sináptica
/
Junção Neuromuscular
Limite:
Animals
Idioma:
En
Revista:
Toxicon
Ano de publicação:
1990
Tipo de documento:
Article