CsrA and TnaB coregulate tryptophanase activity to promote exotoxin-induced killing of Caenorhabditis elegans by enteropathogenic Escherichia coli.
J Bacteriol
; 193(17): 4516-22, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21705596
ABSTRACT
Enteropathogenic Escherichia coli(EPEC) requires the tnaA-encoded enzyme tryptophanase and its substrate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabditis elegans. Here, we demonstrate that the RNA-binding protein CsrA and the tryptophan permease TnaB coregulate tryptophanase activity, through mutually exclusive pathways, to stimulate toxin-mediated paralysis and killing of C. elegans.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Triptofanase
/
Proteínas de Ligação a RNA
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Caenorhabditis elegans
/
Proteínas de Escherichia coli
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Sistemas de Transporte de Aminoácidos
/
Exotoxinas
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Escherichia coli Enteropatogênica
Limite:
Animals
Idioma:
En
Revista:
J Bacteriol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos